Abstract
Cellisthefundermentalunitoflife.Theresearchaboutcellshasalwaysbeenthehottopicinbiologicalfields.Cellseparationisanindispensiblepartincellresearch,anditistheprerequisiteofcellculturinganddignosisingsomediseases.
Inrecentyears,microfluidicshavebroughtgreatconviniencetocellseparation,thereforelargenumbersofpeopledevotethemselvestostudymethodsofcellisolation.PinchedFlowFractionation,duetoitssimplemanipulationandhighapplicationscope,hasdrawnresearchscholars'attention,sinceintroduced.
Inthispaper,wearegoingtoemployimmersedboundary-latticeBoltzmannmethodtostudyPinchedFlowFractionation,andlatticeBoltzmannmethodisutilizedtoconstructfluidfieldandimmersedboundarymethodisusedtosimulatetheinteractionbetweencellsandfluid.
Firstly,themodelandmethodsemploiedinthispaperarevalidatedcarefully.
Thevalidationarebasedonthreeaspects:（1）validationoflid-drivencavityflow;（2）validationoftwo-dimensionalPoiseuilleflow;（3）validationofflowaroundacircularcylinder.Bycomparingthesimulationalresultswithpreviousresults,itiscanbeconcludedthatthemethodsandmodelscansimulatethefluidflowaccurately.
Moreover,theseparationperformancesofdifferentconditionsarestudied.TheseparationeffectsatlowReynoldsnumber（about1）ofdifferentpinchedsegmentwidths,flowratios,andcellmembranestiffnessarediscussed,andthecellbandingpheonomenonisinvestigated.
Theconclusionsarefollowing:
（1）Thepinchedsegmentwidthcaninfluencetheisolationperformancetremendously,Inmostcases,decreasingthepincedsegmentwidthcanimprovetheseparationperformances.
（2）Inordertoseparatetwokindsofcells,thedilutedflowratemustbemorethanthatofparticlesolution.Enlargingthedilutedflowratecanenchancetheseparationperformances.However,whenthedilutedflowrateincreasestosomevalue,itisnoteffectiveanymoretoimprovetheisolationeffects.
（3）Theempiricalformulacanpredicttheoutflowpostionsofcells.Butwhencellsaretooflexible,theformulawillbenotsoeffective.
（4）Whenthedistancebetweentwocellsaretoosmall,cellbandingwilloccur.
Andalso,therelativepositionbetweentwocellswillinfluencethesepartioneffectaswell.Withtheincreaseofdistancebetweentwocells,approximateisolationresultsareobtainedwhensmallcellisinthefront,backandleftpositionoflargecell.However,abetterseparationperformancecanbegotwhensmallcellisintherightpostionoflargecell.
Abstract
Therapiddevelopmentofmobilecommunicationtechnologiesandsmartdevicesformobilehealthcareprovidesanopportunity,thispaperanalyzesthedevelopmentofthetechnologyismaturemobilemedicalnecessityandthestatusquo;andbasedonthearrivaloftheeraofbigdata,usingthecorrelationbetweenthedataforpeopletoprovidemoreintelligentandconvenientthenewmodelofhealthcareservices.
Thispaperanalyzesthestructureandfunctionofdemandformobilehealthcaresystem,andremotefetalmonitoringsystemdesignasanexampletodesign,analyzeacollectionofwearabledevices,theuserofthemobileterminal,medicalinstitutionsterminals,mobilemedicalservicesystemdesignneedstoconsiderthebackgrounddatabaseinteractivefeaturesanddesignprinciplesforthedesignoffuturehealthcaremovesplayedaleadingandguidingresearch.
Finally,wesummarizetheresultsoffetalmonitoringservicesystemdesignpractice,andasamovedesignedtoguidethedevelopmentprospectsofthenewmodelofhealthcareandthepromotionofbasicservicescategory.
Thispaperconstitutesatotaloffiveparts,thefirstpartintroducesthesubjectofsourcesandresearchbackground,purposeandmeaning,andthroughtheliteratureanalyzedthecurrentsituationofmobilemedicalstudies,includingwearabledevices,mobilemedicalcategoryAPPandmobilemedicalsystemthedevelopmentofthreeaspects.Thesecondpartintroducestheconceptofmobilemedicalsystems,functionandconstruction,andanalyzedtelemedicine,mobilemedicalandintelligencetodistinguishbetweenmedicalconceptsandanalyzesthemobilemedicalsystemnetworking,cloudcomputingandbigdatatechnologytosupportthesethreeand,finally,thecommunity,hospitalsandpublicbenefitsbroughtbymobilemedicalsystems.Thethirdpartofthepatientexperienceasthecentralconcernforthehealthofpatients'
needsandexpectations,summedupafewoftheirpsychologicalexpectations,hopingtohavemorespecializedtreatmentandcare,medicaltreatmentprocessmoreconvenient,moreintelligentmonitoring,andsummarizesthemobilemedicalsystemdesignprinciples,includingtheprincipleofthescene,theprincipleoffaulttolerance,easeofprinciple,theprincipleofemotion,privacyprinciples,theprincipleofconsistency,themodularprinciple.Thefourthpartisapartofdesignpractice,researchanddesignthroughusersurveys,thischapterconstructsasetofremotefetalmonitoringsoftwaresystem,themobilephonesidebypregnantwomen,doctorsdigitizingtabletandback-enddatamanagementsystemtoachieveallthedataexchange,showsindetailthedesignofinteractivedesignservicestoremotefetalheartratemonitoringsystemprocessesandthevarioussubsystems.Thefifthpartsummarizesthefindingsofthisproject,aswellasrelatedshortcomingsofthestudy.Analysisofthefuturedevelopmenttrendofpersonalizedmobilemedical,socialandinformationtechnology.Subsequentresearchanddesigntomakeacertainoutlook.
ABSTRACT
Duetotheacademicmonopolizationandotherproblems,Traditionalacademicjournalsandpaidelectronicjournalsaresufferingfromaseriouscrisis.Atthesametime,fundsshortageandlackofstoragespaceforliteraturepushedthelibrarytomakethetransformation.Inthisenvironment,OpenAccess,onenewpublishingmodelemergedindevelopedcountries.
Comparedtotheopenaccessofothercountries,whichiscomingtomaturity,Chineseopenaccessisintheinfancy.Soweurgentneedtolearnfromforeignexperience,sothatouropenaccesscangetrapiddevelopment.
Firstofall,inthisthesis,basedontheimplementationmechanismandcommonprotocols,combinedwiththeresearchresultofdomesticandforeignscholars,thedefinitionofopenaccesshasbeenredefined.Then,byusingtheSWOTanalyticalmethod,thispaperdoesqualitativeandquantitativeanalysisonexternalopportunities,threatsandinternalstrengths,weaknessesofChineseopenaccess.Atlast,basedontheanalysisoftheSWOTmatrixstructureandtheactualcaseofSpringer,thispapermakesadepthanalysisonSO,WO,ST,WT.
Thispaperisdividedintofivechapters:Thefirstchaptermainlyproposesthebackgroundofthisresearch.BesidesclearingtheobjectofstudyistheopenaccessofChineseacademicjournalandSpringerOpenAccessJournals.Andthen,thischaptersummariestheresearchstatusofopenaccess;thesecondchapteropenaccessoverviewstheopenaccess,basedontheimplementationmechanismandcommonprotocols,bydiscussingtheresearchresultofdomesticandforeignscholars,thedefinitionofopenaccesshasbeenredefined;thethirdchapterintroducesthedevelopmentstatusofSpringer,whichpavethewayforlatercasestudies;thefourthchapteranalyzedtheimplementingopenaccessinChineseacademicjournalsfromthestrengths,weaknesses,opportunitiesandthreats,whicharethefouraspectsofSWOT;thefifthchapterisbasedontheSWOTmatrixstructure,combinedwiththeexperienceofSpringer,analysestheSO,WO,ST,WT.Atthesametime,referencetotheexperimentsofSpringeropenaccess,thischaptermakessomesuggestionsforChineseopenaccess.Thelastistheconclusionwhichevaluateonthewholeresearchworkanddescribesthefutureresearchobjectives.
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