关于内皮类论文范本,与抑郁症首次发病患者内皮祖细胞数量和功能变化的初步相关本科毕业论文中期报告

本文是一篇内皮论文范文,关于内皮类自考毕业论文开题报告,关于抑郁症首次发病患者内皮祖细胞数量和功能变化的初步相关硕士学位毕业论文范文。适合内皮及细胞及数量方面的的大学硕士和本科毕业论文以及内皮相关开题报告范文和职称论文写作参考文献资料下载。

【摘 要 】目的：对抑郁症首次发病的患者的内皮祖细胞数量和功能变化进行初步研究.方法：根据国际疾病分类第十次修订本首发重性抑郁症的诊断标准判断中年抑郁症患者20例是否合格,结果表明,24项HAMD抑郁量表评分>35分,定为观察组.选择正常志愿者20例,判断24项HAMD抑郁量表,评分<8分,要求志愿者的性别、年龄、受教育程度均与观察组相当,设为对照组.分离外周血内皮祖细胞并进行体外培养,对于EPC生长情况进行观察和记录,通过分析多项指标分析EPC各项,判断具有分化为内皮细胞的特性,进行统计学分析.结果：观察组外周血EPC细胞数量和细胞增殖率低于对照组,观察组血清白细胞介素水平超过对照组,超敏反应蛋白水平高于对照组,两个数据差异均有统计学意义（均P<0.05）；（2）Spearman相关分析显示,患者组IL-6和TNF―d水平与循环EPCs的数量和增殖率呈负相关（均P<0.05）；（3）多元线性逐步回归分析显示,HAMD总分和IL-6水平是循环EPC数量的独立影响因素（均P<0.05）.结论：抑郁症首次发病患者EPC数量减少,从而证明内皮祖细胞数量减少、功能减退.

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【关 键 词 】抑郁症、内皮祖细胞数量及功能

【key words 】changes in the number and function of endothelial progenitor cells in patients with first onset of depression were studied. Methods： The revised according to the International Classification of Diseases, Tenth diagnostic criteria for major depression of the first judgment of 20 patients aged depression is qualified, the results showed that 24 HAMD depression scale score> 35 points, as the observation group. Choose healthy volunteers, 20 cases judged 24 HAMD depression scale, score <8 points, requiring volunteers gender, age, educational level and the observation group were quite, as the control group. Peripheral blood progenitor cells isolated and cultured in vitro for EPC growth were observed and recorded, analyzed a number of indicators by analyzing the EPC to determine the characteristics differentiate into endothelial cells, were statistically analyzed. Results： The number of peripheral blood EPC cells and cell proliferation rate than the control group, serum interleukin observation group than in the control group levels, hypersensitivity higher protein levels, two data differences were statistically significant （both P <0.05）； （2） Spearman correlation analysis showed that patients IL-6 and TNF-d levels and the number of circulating EPCs and the proliferation rate was negatively correlated （all P <0.05）； （3） Multiple linear Stepwise regression analysis showed that, HAMD total score and IL-6 levels were independent predictors of the number of circulating EPC （all P <0.05）. Conclusion： The number of EPC first onset of depression in patients with reduced, thereby reducing the number of permits Mingneipizu cell dysfunction.

【key words 】depression, the number and function of endothelial progenitor cells

【中图分类号】R714.6 【文献标识码】B【文章编号】1004-4949（2014）04-0051-01

随着社会不断发展,人们生活压力与日剧增,越来越多的人患各种心理精神疾病,抑郁症是较为严重的一种心理疾病,抑郁患者通常表现为遇事消极怠慢,思考问题不乐观,生活态度消极低沉.有资料显示,